Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development.
نویسندگان
چکیده
A rat lung cell population had been treated with benzo(a)pyrene, and a set of different epithelial cell lines was derived from it. These cell lines carried either a wild-type or mutant p53 gene and represented grading states of neoplastic development. We demonstrate here that the cells lacking both wild-type p53 alleles display a significant decrease in survival after gamma-irradiation with doses of 2 to 12 Gy, compared with their counterparts carrying wild-type p53 alleles. This is the first reported model in which cells bearing a mutation of the p53 gene display enhanced sensitivity to ionizing radiation.
منابع مشابه
Development in Rat Lung Embryo Epithelial Cells during Neoplastic Gene Mutation and Increased Radiosensitivity
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عنوان ژورنال:
- Cancer research
دوره 54 13 شماره
صفحات -
تاریخ انتشار 1994